Vasoconstrictors in hepatorenal syndrome – A critical review
نویسندگان
چکیده
منابع مشابه
Hepatorenal syndrome: a critical update.
Acute kidney injury (AKI) is common in cirrhotic patients with ascites. Although not the primary etiology of AKI in cirrhotic patients, hepatorenal syndrome (HRS) is a unique form of AKI that develops only in cirrhotic patients. Intense renal vasoconstriction is the hallmark of HRS. Different mechanisms contribute to renal vasoconstriction, with splanchnic vasodilatation and reduced effective b...
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BACKGROUND AND AIMS Hepatorenal syndrome is a severe complication of cirrhosis and associates with significant mortality. Vasoconstrictor medications improve renal function in patients with hepatorenal syndrome. However, it is unclear to what extent changes in serum creatinine during treatment may act as a surrogate for changes in mortality. We have performed a meta-analysis of randomized trial...
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Hypertension is a disease of relatively normal blood flow and increased vascular resistance. The search for neural and humoral vasoconstrictors to explain this pattern has not produced convincing evidence in most cases. Autoregulatory vasoconstriction is an alternative explanation supported by Borst, Ledingbam and others; the validity of this idea is strengthened by frequent observations of rel...
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Hepatorenal syndrome (HRS) is a common complication of advanced cirrhosis characterized not only by renal failure but also by marked alterations in systemic haemodynamics and activity of endogenous vasoactive systems. Renal failure is due to a severe vasoconstriction of the renal circulation. The pathogenesis of HRS is not completely understood but it is probably the result of extreme underfill...
متن کاملReview article: hepatorenal syndrome--definitions and diagnosis.
Hepatorenal syndrome (HRS) is a severe complication of cirrhosis that develops in the final phase of the disease. Two types of HRS exist. Type 1 is defined by a rapid reduction of renal function and in type 2 HRS the reduction of renal function is slowly progressive. Type 1 HRS is diagnosed when the serum creatinine level increases by more than 50% of the baseline value to above 133 micromol/L....
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ژورنال
عنوان ژورنال: Annals of Hepatology
سال: 2019
ISSN: 1665-2681
DOI: 10.1016/j.aohep.2018.12.002